SLU-PP 332
5 mg
Exercise-mimetic molecule studied for its activation of ERRα receptors. In animal models it has been investigated for fatty-acid oxidation, glycogen sparing and aerobic capacity.
- Studied for endurance capacity in animal models
- Investigated for fatty acids as oxidative substrate
- Studied for its effect on lean-mass preservation
- Investigated for mitochondrial efficiency
Scientific context
Origin, mechanism, and research
Developed at Saint Louis University (the Thomas Burris and Patti labs) and first described in 2022, SLU-PP-332 is a small synthetic molecule — not a peptide — nicknamed the "exercise mimetic." Its regulatory status is exclusively preclinical: all available efficacy data comes from mouse studies; it has not been replicated in humans, and no clinical trials are registered. It works as a pan-selective agonist of the three estrogen-related receptors (ERRα, ERRβ, ERRγ), with greater affinity for ERRα, activating oxidative-phosphorylation genes, beta-oxidation enzymes, and mitochondrial biogenesis. In mice, it increased oxidative muscle fibers and improved aerobic endurance capacity without the animal exercising.
Information for educational and informational purposes, based on public sources; it does not constitute medical advice. Product for laboratory research use only — not for human consumption.
